GW441756

Across CCLE and GDSC cell-line panels, response to GW441756 is significantly associated with the protein abundance of multiple proteins, with BONE cell lines showing a particularly strong set of associations.

The most reproducible GW441756 response-associated proteins across cancer lineages are BCL2L1, GNB2, and NASP, each associated with drug response in up to 10 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, GW441756 response versus BCL2L1 protein abundance in BONE (Pearson r = -0.52).

Protein abundance biomarkers of GW441756 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	BCL2L1 →	-1.117	-0.513	<.001	<.001	3	10
CNS	GNB2 →	-0.676	-0.287	<.001	.001	3	10
LARGE_INTESTINE	NASP →	+1.205	+0.457	.003	.010	3	10
LUNG_NSCLC_LUSC	NDUFA10 →	-0.766	-0.444	.019	.012	3	9
BLOOD_Lymphoma	ECHDC2 →	-1.645	-0.357	.011	.004	3	9
SOFT_TISSUE	NCEH1 →	-3.646	-0.390	.009	.027	3	9

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GW441756 response vs BCL2L1 — BONE

Explore this scatter interactively →