GSK690693

Across CCLE and GDSC cell-line panels, response to GSK690693 is significantly associated with the protein abundance of multiple proteins, with BONE cell lines showing a particularly strong set of associations.

The most reproducible GSK690693 response-associated proteins across cancer lineages are CCT7, CDK1, and UBL5, each associated with drug response in up to 9 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, GSK690693 response versus CCT7 protein abundance in BONE (Pearson r = 0.45).

Protein abundance biomarkers of GSK690693 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	CCT7 →	+1.041	+0.954	<.001	.002	3	9
LUNG_SCLC	CDK1 →	+0.915	+0.602	<.001	.012	3	9
BONE	UBL5 →	+0.722	+1.077	.009	.013	3	9
LARGE_INTESTINE	PPP2R1A →	+0.749	+0.630	.012	.005	3	8
BLOOD_Leukemia	CHD4 →	+0.376	+0.888	<.001	.007	3	8
LARGE_INTESTINE	PPP2CA →	+0.859	+0.496	.032	.019	2	9

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GSK690693 response vs CCT7 — BONE

Explore this scatter interactively →