GSK626616AC

Across CCLE and GDSC cell-line panels, response to GSK626616AC is significantly associated with the shRNA pathway dependency of multiple pathways, with PANCREAS cell lines showing a particularly strong set of associations.

The most reproducible GSK626616AC response-associated pathways across cancer lineages are 5-phosphoribose 1-diphosphate metabolic process, 5-phosphoribose 1-diphosphate biosynthetic process, and Negative regulation of T cell activation, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, GSK626616AC response versus 5-phosphoribose 1-diphosphate metabolic process shRNA pathway dependency in PANCREAS (Pearson r = 0.34).

Shrna pathway dependency biomarkers of GSK626616AC response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	5-phosphoribose 1-diphosphate metabolic process →	+1.306	+0.345	.030	.014	3	8
PANCREAS	5-phosphoribose 1-diphosphate biosynthetic process →	+1.306	+0.345	.030	.014	3	8
SOFT_TISSUE	Negative regulation of T cell activation →	-0.372	-0.488	.004	.021	3	8
SOFT_TISSUE	Negative regulation of lymphocyte activation →	-0.337	-0.735	<.001	.025	3	8
LARGE_INTESTINE	Intermembrane lipid transfer →	+1.182	+0.473	.013	.025	3	7
SOFT_TISSUE	Branched-chain amino acid catabolic process →	+1.662	+0.483	.029	.040	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GSK626616AC response vs 5-phosphoribose 1-diphosphate metabolic process — PANCREAS

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