GSK626616AC

Across CCLE and GDSC cell-line panels, response to GSK626616AC is significantly associated with the protein-level pathway activity of multiple pathways, with LARGE_INTESTINE cell lines showing a particularly strong set of associations.

The most reproducible GSK626616AC response-associated pathways across cancer lineages are Megakaryocyte development, Calcium ion homeostasis, and Phagocytosis, each associated with drug response in up to 10 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, GSK626616AC response versus Megakaryocyte development protein-level pathway activity in LARGE_INTESTINE (Pearson r = -0.33).

Protein-level pathway activity biomarkers of GSK626616AC response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Megakaryocyte development →	-0.475	-0.386	.022	.003	3	10
OVARY	Calcium ion homeostasis →	-0.305	-0.551	.008	.003	3	9
CNS	Phagocytosis →	-0.339	-0.360	<.001	<.001	3	9
STOMACH	Regulation of protein localization to plasma membrane →	-0.300	-0.435	.028	.046	2	10
LARGE_INTESTINE	Positive regulation of plasma membrane repair →	-0.160	-0.413	<.001	<.001	3	9
CNS	Cellular response to xenobiotic stimulus →	-0.225	-0.453	.001	.005	3	9

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GSK626616AC response vs Megakaryocyte development — LARGE_INTESTINE

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