GSK3337463A

Across CCLE and GDSC cell-line panels, response to GSK3337463A is significantly associated with the total protein of multiple proteins, with LARGE_INTESTINE cell lines showing a particularly strong set of associations.

The most reproducible GSK3337463A response-associated proteins across cancer lineages are Transglutaminase, YAP, and 4E-BP1, each associated with drug response in up to 7 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, GSK3337463A response versus Transglutaminase total protein in LARGE_INTESTINE (Pearson r = -0.55).

Total protein biomarkers of GSK3337463A response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Transglutaminase →	-0.552	-0.338	.019	.008	3	7
LARGE_INTESTINE	YAP →	-0.430	-0.452	.001	.006	3	7
UPPER_AERODIGESTIVE_TRACT	4E-BP1 →	+0.836	+0.370	<.001	.003	3	6
STOMACH	PAI-1 →	-1.572	-0.292	.024	.031	1	7
CNS	Chk1_pS345 →	+0.240	+0.378	.044	.016	3	5
BREAST	JAK2 →	+0.346	+0.328	.019	.027	2	5

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GSK3337463A response vs Transglutaminase — LARGE_INTESTINE

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