GSK319347A

Across CCLE and GDSC cell-line panels, response to GSK319347A is significantly associated with the total protein of multiple proteins, with LARGE_INTESTINE cell lines showing a particularly strong set of associations.

The most reproducible GSK319347A response-associated proteins across cancer lineages are SCD1, ACVRL1, and PKC-a, each associated with drug response in up to 4 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, GSK319347A response versus SCD1 total protein in LARGE_INTESTINE (Pearson r = -0.62).

Total protein biomarkers of GSK319347A response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SCD1 →	-0.419	-0.324	.035	.012	3	4
BLOOD_Myeloma	ACVRL1 →	-0.343	-0.237	.023	.032	3	4
CNS	PKC-a →	+1.107	+0.526	.005	.041	3	3
CNS	VEGFR2 →	-1.269	-0.463	.001	.008	3	3
BLOOD_Leukemia	p62 Lck ligand →	-0.804	-0.342	<.001	<.001	3	3
BLOOD_Myeloma	VAV1 →	-1.363	-0.242	.003	.024	3	3

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GSK319347A response vs SCD1 — LARGE_INTESTINE

Explore this scatter interactively →