GSK2830371A

Across CCLE and GDSC cell-line panels, response to GSK2830371A is significantly associated with the total protein of multiple proteins, with LARGE_INTESTINE cell lines showing a particularly strong set of associations.

The most reproducible GSK2830371A response-associated proteins across cancer lineages are Transglutaminase, c-Met, and Stathmin, each associated with drug response in up to 5 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, GSK2830371A response versus Transglutaminase total protein in LARGE_INTESTINE (Pearson r = -0.50).

Total protein biomarkers of GSK2830371A response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Transglutaminase →	-0.834	-0.314	.006	.041	3	5
SKIN	c-Met →	-0.393	-0.384	.006	.016	3	5
LIVER	Stathmin →	+0.213	+0.492	.007	.022	3	5
BONE	IGFBP2 →	+2.472	+0.518	.002	.001	3	5
BONE	Tuberin_pT1462 →	+0.325	+0.490	.012	.006	3	5
URINARY_TRACT	MSH6 →	+0.863	+0.262	.019	.026	3	5

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GSK2830371A response vs Transglutaminase — LARGE_INTESTINE

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