GSK2606414

Across CCLE and GDSC cell-line panels, response to GSK2606414 is significantly associated with the protein-level pathway activity of multiple pathways, with URINARY_TRACT cell lines showing a particularly strong set of associations.

The most reproducible GSK2606414 response-associated pathways across cancer lineages are Transferrin transport, Regulation of plasma membrane repair, and Regulation of long-term synaptic potentiation, each associated with drug response in up to 9 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, GSK2606414 response versus Transferrin transport protein-level pathway activity in URINARY_TRACT (Pearson r = -0.52).

Protein-level pathway activity biomarkers of GSK2606414 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Transferrin transport →	-0.211	-0.535	.032	.023	2	9
BONE	Regulation of plasma membrane repair →	-0.351	-0.363	<.001	.015	3	8
KIDNEY	Regulation of long-term synaptic potentiation →	-0.552	-0.439	.007	.018	3	7
BONE	Positive regulation of long-term synaptic potentiation →	-0.714	-0.455	.008	.001	3	7
BREAST	DGMP metabolic process →	+0.483	+0.444	.010	.004	3	7
URINARY_TRACT	Protein targeting to vacuole involved in autophagy →	-0.277	-0.571	.015	.025	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GSK2606414 response vs Transferrin transport — URINARY_TRACT

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