GSK2578215A

Across CCLE and GDSC cell-line panels, response to GSK2578215A is significantly associated with the shRNA pathway dependency of multiple pathways, with BONE cell lines showing a particularly strong set of associations.

The most reproducible GSK2578215A response-associated pathways across cancer lineages are Intermembrane lipid transfer, Secondary metabolite biosynthetic process, and Aspartate metabolic process, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, GSK2578215A response versus Intermembrane lipid transfer shRNA pathway dependency in BONE (Pearson r = 0.78).

Shrna pathway dependency biomarkers of GSK2578215A response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Intermembrane lipid transfer →	+1.786	+0.604	.019	.041	2	8
KIDNEY	Secondary metabolite biosynthetic process →	+2.310	+0.536	.006	.017	3	7
BONE	Aspartate metabolic process →	+2.121	+0.560	<.001	.002	3	6
SOFT_TISSUE	Regulation of endoplasmic reticulum tubular network organization →	+1.781	+0.633	<.001	.047	3	6
KIDNEY	Intestinal D-glucose absorption →	+1.131	+0.316	.038	.023	3	6
OVARY	Regulation of transferase activity →	-0.107	-0.382	<.001	.016	3	6

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GSK2578215A response vs Intermembrane lipid transfer — BONE

Explore this scatter interactively →