GSK2256098C

Across CCLE and GDSC cell-line panels, response to GSK2256098C is significantly associated with the shRNA pathway dependency of multiple pathways, with LARGE_INTESTINE cell lines showing a particularly strong set of associations.

The most reproducible GSK2256098C response-associated pathways across cancer lineages are Regulation of mature B cell apoptotic process, Negative regulation of mature B cell apoptotic process, and Regulation of cAMP-dependent protein kinase activity, each associated with drug response in up to 7 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, GSK2256098C response versus Regulation of mature B cell apoptotic process shRNA pathway dependency in LARGE_INTESTINE (Pearson r = 0.58).

Shrna pathway dependency biomarkers of GSK2256098C response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Regulation of mature B cell apoptotic process →	+1.593	+0.512	<.001	.004	3	7
LARGE_INTESTINE	Negative regulation of mature B cell apoptotic process →	+1.593	+0.512	<.001	.004	3	7
CNS	Regulation of cAMP-dependent protein kinase activity →	+1.455	+0.481	.009	.014	3	7
LARGE_INTESTINE	Intermembrane lipid transfer →	+1.519	+0.501	<.001	.009	3	7
OVARY	Cellular response to platelet-derived growth factor stimulus →	-1.020	-0.526	.019	.016	3	7
SOFT_TISSUE	Branched-chain amino acid metabolic process →	+1.980	+0.645	.002	<.001	3	6

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GSK2256098C response vs Regulation of mature B cell apoptotic process — LARGE_INTESTINE

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