GSK1070916

Across CCLE and GDSC cell-line panels, response to GSK1070916 is significantly associated with the total protein of multiple proteins, with BLOOD_Leukemia cell lines showing a particularly strong set of associations.

The most reproducible GSK1070916 response-associated proteins across cancer lineages are S6_pS235_S236, S6_pS240_S244, and p62 Lck ligand, each associated with drug response in up to 7 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, GSK1070916 response versus S6_pS235_S236 total protein in BLOOD_Leukemia (Pearson r = -0.40).

Total protein biomarkers of GSK1070916 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	S6_pS235_S236 →	-1.824	-1.144	<.001	.016	3	7
URINARY_TRACT	S6_pS240_S244 →	-2.240	-1.469	.012	.031	3	7
BLOOD_Myeloma	p62 Lck ligand →	-2.543	-1.384	<.001	.006	3	6
SOFT_TISSUE	STAT5a →	-1.455	-1.347	.009	.011	3	6
SKIN	SF2 →	+0.255	+0.616	.013	.003	3	6
BREAST	Cyclin-E1 →	+0.938	+1.084	.007	.006	3	6

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GSK1070916 response vs S6_pS235_S236 — BLOOD_Leukemia

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