GSK1059615

Across CCLE and GDSC cell-line panels, response to GSK1059615 is significantly associated with the RNA expression of multiple genes, with LUNG_NSCLC_LUSC cell lines showing a particularly strong set of associations.

The most reproducible GSK1059615 response-associated genes across cancer lineages are GPAT3, NOL3, and TNFSF12, each associated with drug response in up to 9 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, GSK1059615 response versus GPAT3 RNA expression in LUNG_NSCLC_LUSC (Pearson r = -0.57).

Rna expression biomarkers of GSK1059615 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	GPAT3 →	-2.441	-0.918	.019	.009	3	9
OVARY	NOL3 →	-1.157	-0.811	.001	.011	3	8
CNS	TNFSF12 →	-1.906	-0.292	<.001	.003	3	7
SOFT_TISSUE	NOS3 →	-3.584	-0.854	.028	.041	2	8
PANCREAS	PSMB10 →	-0.794	-0.518	.020	.022	3	7
LUNG_NSCLC_LUSC	SLC22A18 →	-1.634	-0.972	.025	.011	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GSK1059615 response vs GPAT3 — LUNG_NSCLC_LUSC

Explore this scatter interactively →