GSK-LSD1

Across CCLE and GDSC cell-line panels, response to GSK-LSD1 is significantly associated with the pathway activity of multiple pathways, with URINARY_TRACT cell lines showing a particularly strong set of associations.

The most reproducible GSK-LSD1 response-associated pathways across cancer lineages are Renal filtration, Intracellular calcium ion homeostasis, and Leukemia inhibitory factor signaling pathway, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, GSK-LSD1 response versus Renal filtration pathway activity in URINARY_TRACT (Pearson r = -0.33).

Pathway activity biomarkers of GSK-LSD1 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Renal filtration →	-0.237	-0.195	.038	.011	3	8
LUNG_NSCLC_LUSC	Intracellular calcium ion homeostasis →	-0.068	-0.269	.026	.005	3	8
BLOOD_Myeloma	Leukemia inhibitory factor signaling pathway →	-0.196	-0.377	.017	.044	2	8
LUNG_SCLC	RNA folding →	+0.122	+0.526	.004	.014	3	7
OVARY	Ketone biosynthetic process →	+0.137	+0.385	.015	.037	3	7
LUNG_NSCLC_LUAD	Regulation of amyloid fibril formation →	-0.076	-0.385	.015	.010	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GSK-LSD1 response vs Renal filtration — URINARY_TRACT

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