GNF-2

Across CCLE and GDSC cell-line panels, response to GNF-2 is significantly associated with the mutation status of multiple genes, with LUNG_SCLC cell lines showing a particularly strong set of associations.

The most reproducible GNF-2 response-associated genes across cancer lineages are CNTNAP5, DOCK2, and TP53, each associated with drug response in up to 1 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The box plot shows the strongest observed association, GNF-2 response grouped by CNTNAP5 status in LUNG_SCLC.

Mutation status biomarkers of GNF-2 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CNTNAP5 →	+2.169	+0.214	.027	.026	3	1
BLOOD_Lymphoma	DOCK2 →	+2.052	+0.190	.040	.033	3	1
BLOOD_Lymphoma	TP53 →	+0.704	+0.173	.022	.016	3	1
LUNG_SCLC	TPTE →	-2.807	-0.210	.027	.029	3	1
BLOOD_Leukemia	DPP6 →	+2.667	+0.612	.040	.001	3	1
BLOOD_Leukemia	GCC2 →	+2.667	+0.405	.040	.034	3	1

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GNF-2 response by CNTNAP5 status — LUNG_SCLC

Explore this box plot interactively →