GNF-2

Across CCLE and GDSC cell-line panels, response to GNF-2 is significantly associated with the pathway activity of multiple pathways, with LUNG_NSCLC_LUAD cell lines showing a particularly strong set of associations.

The most reproducible GNF-2 response-associated pathways across cancer lineages are Fucose transmembrane transport, Positive regulation of termination of DNA-templated transcription, and Retina vasculature development in camera-type eye, each associated with drug response in up to 6 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, GNF-2 response versus Fucose transmembrane transport pathway activity in LUNG_NSCLC_LUAD (Pearson r = -0.72).

Pathway activity biomarkers of GNF-2 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Fucose transmembrane transport →	-0.293	-0.506	.047	.038	3	5
CNS	Positive regulation of termination of DNA-templated transcription →	+0.134	+0.371	.002	.005	3	5
CNS	Retina vasculature development in camera-type eye →	+0.164	+0.405	.014	.029	3	5
LUNG_NSCLC_LUAD	Regulation of cyclin-dependent protein serine/threonine kinase activity →	+0.089	+0.483	.041	.015	3	5
LARGE_INTESTINE	Regulation of kidney development →	-0.153	-0.560	.014	.033	3	5
OESOPHAGUS	Recombinational repair →	+0.086	+0.471	.045	.002	3	5

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GNF-2 response vs Fucose transmembrane transport — LUNG_NSCLC_LUAD

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