Foretinib

Across CCLE and GDSC cell-line panels, response to Foretinib is significantly associated with the total protein of multiple proteins, with BLOOD_Lymphoma cell lines showing a particularly strong set of associations.

The most reproducible Foretinib response-associated proteins across cancer lineages are VEGFR2, p70-S6K, and AMPK_alpha, each associated with drug response in up to 7 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Foretinib response versus VEGFR2 total protein in BLOOD_Lymphoma (Pearson r = -0.39).

Total protein biomarkers of Foretinib response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	VEGFR2 →	-1.339	-0.529	.004	.006	3	7
KIDNEY	p70-S6K →	+0.426	+0.570	.017	.006	3	7
LUNG_SCLC	AMPK_alpha →	-0.467	-0.466	.008	.035	3	6
LIVER	C-Raf(BD610151) →	+1.030	+0.607	.005	.024	3	5
BREAST	mTOR_pS2448 →	-0.262	-0.706	.030	<.001	3	5
URINARY_TRACT	GSK-3_pS9 →	-1.120	-0.778	.002	.005	3	5

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Foretinib response vs VEGFR2 — BLOOD_Lymphoma

Explore this scatter interactively →