Flavopiridol

Across CCLE and GDSC cell-line panels, response to Flavopiridol is significantly associated with the RNA expression of multiple genes, with BLOOD_Leukemia cell lines showing a particularly strong set of associations.

The most reproducible Flavopiridol response-associated genes across cancer lineages are BCL2L1, RRAS, and SIL1, each associated with drug response in up to 10 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Flavopiridol response versus BCL2L1 RNA expression in BLOOD_Leukemia (Pearson r = -0.29).

Rna expression biomarkers of Flavopiridol response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	BCL2L1 →	-1.395	-0.304	.006	.011	3	10
BREAST	RRAS →	-1.432	-0.586	.003	.001	3	9
LUNG_SCLC	SIL1 →	-0.978	-0.308	.004	.033	3	9
URINARY_TRACT	IL15 →	-1.592	-0.652	.003	.006	3	9
KIDNEY	RHBDF1 →	-0.767	-0.495	.047	.013	3	9
LUNG_NSCLC_LUSC	TSPAN4 →	-2.614	-1.079	.023	.032	3	8

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Flavopiridol response vs BCL2L1 — BLOOD_Leukemia

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