Flavopiridol

Across CCLE and GDSC cell-line panels, response to Flavopiridol is significantly associated with the total protein of multiple proteins, with KIDNEY cell lines showing a particularly strong set of associations.

The most reproducible Flavopiridol response-associated proteins across cancer lineages are PEA-15, Annexin_VII, and PDK1, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Flavopiridol response versus PEA-15 total protein in KIDNEY (Pearson r = -0.39).

Total protein biomarkers of Flavopiridol response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	PEA-15 →	-0.461	-0.547	.007	.043	3	8
BLOOD_Lymphoma	Annexin_VII →	-0.851	-0.883	.001	.017	3	7
BLOOD_Myeloma	PDK1 →	-0.328	-0.373	.025	.018	3	7
SOFT_TISSUE	Cyclin-E2 →	+0.776	+0.774	.005	.014	3	6
LUNG_NSCLC_LUSC	G6PD →	-2.691	-0.626	.045	.004	3	5
CNS	Acetyl-a-Tubulin-Lys40 →	+0.635	+0.406	.009	.003	3	5

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Flavopiridol response vs PEA-15 — KIDNEY

Explore this scatter interactively →