FY069

Across CCLE and GDSC cell-line panels, response to FY069 is significantly associated with the shRNA dependency of multiple gene dependencies, with BONE cell lines showing a particularly strong set of associations.

The most reproducible FY069 response-associated gene dependencies across cancer lineages are VIRMA, SLC3A2, and CLGN, each associated with drug response in up to 7 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, FY069 response versus VIRMA shRNA dependency in BONE (Pearson r = 0.88).

Shrna dependency biomarkers of FY069 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene dependencie	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	VIRMA →	+0.315	+1.339	.009	.036	3	7
OESOPHAGUS	SLC3A2 →	-0.207	-0.589	.026	.028	3	7
BONE	CLGN →	+0.206	+0.919	.041	.001	3	7
OESOPHAGUS	ATAD2B →	+0.097	+0.406	.009	.029	3	6
KIDNEY	TMOD4 →	-0.156	-0.613	.003	.028	3	6
KIDNEY	GNAI3 →	-0.245	-0.431	<.001	.044	3	6

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FY069 response vs VIRMA — BONE

Explore this scatter interactively →