FTI-277

Across CCLE and GDSC cell-line panels, response to FTI-277 is significantly associated with the shRNA pathway dependency of multiple pathways, with LUNG_SCLC cell lines showing a particularly strong set of associations.

The most reproducible FTI-277 response-associated pathways across cancer lineages are RNA splicing, via endonucleolytic cleavage and ligation, Protein exit from endoplasmic reticulum, and Type I interferon-mediated signaling pathway, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, FTI-277 response versus RNA splicing, via endonucleolytic cleavage and ligation shRNA pathway dependency in LUNG_SCLC (Pearson r = 0.63).

Shrna pathway dependency biomarkers of FTI-277 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	RNA splicing, via endonucleolytic cleavage and ligation →	+0.180	+0.268	.031	.005	3	8
BONE	Protein exit from endoplasmic reticulum →	+0.221	+0.535	.049	.016	3	7
UPPER_AERODIGESTIVE_TRACT	Type I interferon-mediated signaling pathway →	-1.498	-0.361	.001	<.001	3	7
BONE	Commissural neuron axon guidance →	-1.789	-0.596	<.001	.001	3	7
UPPER_AERODIGESTIVE_TRACT	Interferon-mediated signaling pathway →	-1.380	-0.362	.001	<.001	3	7
CNS	Regulation of interleukin-6-mediated signaling pathway →	-1.268	-0.478	.012	.003	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FTI-277 response vs RNA splicing, via endonucleolytic cleavage and ligation — LUNG_SCLC

Explore this scatter interactively →