FGFR_0939

Across CCLE and GDSC cell-line panels, response to FGFR_0939 is significantly associated with the mutation status of multiple genes, with SKIN cell lines showing a particularly strong set of associations.

The most reproducible FGFR_0939 response-associated genes across cancer lineages are CSMD2, TEP1, and FCGBP, each associated with drug response in up to 4 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The box plot shows the strongest observed association, FGFR_0939 response grouped by CSMD2 status in SKIN.

Mutation status biomarkers of FGFR_0939 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CSMD2 →	+1.399	+0.256	.044	.030	3	4
LUNG_SCLC	TEP1 →	+2.900	+0.268	.015	.046	3	3
OVARY	FCGBP →	+3.029	+0.336	.014	.013	3	3
OESOPHAGUS	FLG →	+2.541	+0.299	.001	.010	3	3
BLOOD_Leukemia	GSE1 →	+2.321	+0.259	.024	.027	3	3
BLOOD_Leukemia	PXDNL →	+2.115	+0.256	.009	.014	3	3

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FGFR_0939 response by CSMD2 status — SKIN

Explore this box plot interactively →