Etoposide

Across CCLE and GDSC cell-line panels, response to Etoposide is significantly associated with the shRNA dependency of multiple gene dependencies, with SOFT_TISSUE cell lines showing a particularly strong set of associations.

The most reproducible Etoposide response-associated gene dependencies across cancer lineages are JUNB, PLA2G12B, and UBA5, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Etoposide response versus JUNB shRNA dependency in SOFT_TISSUE (Pearson r = -0.65).

Shrna dependency biomarkers of Etoposide response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene dependencie	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	JUNB →	-0.190	-1.260	.019	.010	3	8
CNS	PLA2G12B →	-0.276	-1.106	.017	.012	3	8
KIDNEY	UBA5 →	-0.247	-1.162	.014	.007	3	7
KIDNEY	SMPD5 →	+0.427	+1.327	.003	.003	3	7
BLOOD_Leukemia	OPN1LW →	+0.276	+1.247	.020	.001	3	7
LARGE_INTESTINE	ADAMTS2 →	+0.216	+1.788	.019	<.001	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Etoposide response vs JUNB — SOFT_TISSUE

Explore this scatter interactively →