Erlotinib

Across CCLE and GDSC cell-line panels, response to Erlotinib is significantly associated with the shRNA pathway dependency of multiple pathways, with PANCREAS cell lines showing a particularly strong set of associations.

The most reproducible Erlotinib response-associated pathways across cancer lineages are Pyrimidine nucleoside monophosphate biosynthetic process, Nucleoside phosphate catabolic process, and tRNA wobble position uridine thiolation, each associated with drug response in up to 7 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Erlotinib response versus Pyrimidine nucleoside monophosphate biosynthetic process shRNA pathway dependency in PANCREAS (Pearson r = 0.42).

Shrna pathway dependency biomarkers of Erlotinib response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Pyrimidine nucleoside monophosphate biosynthetic process →	+0.305	+0.820	.004	<.001	3	7
LUNG_NSCLC_LUSC	Nucleoside phosphate catabolic process →	+0.294	+0.891	.027	<.001	3	7
BLOOD_Myeloma	tRNA wobble position uridine thiolation →	-2.348	-0.529	.011	.019	3	7
URINARY_TRACT	Regulation of pinocytosis →	-2.023	-0.812	<.001	<.001	3	7
BLOOD_Leukemia	Gluconeogenesis →	+0.297	+0.510	.037	.019	3	7
BLOOD_Leukemia	Pyrimidine-containing compound metabolic process →	+0.195	+0.547	.032	.002	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Erlotinib response vs Pyrimidine nucleoside monophosphate biosynthetic process — PANCREAS

Explore this scatter interactively →