Erlotinib

Across CCLE and GDSC cell-line panels, response to Erlotinib is significantly associated with the pathway activity of multiple pathways, with UPPER_AERODIGESTIVE_TRACT cell lines showing a particularly strong set of associations.

The most reproducible Erlotinib response-associated pathways across cancer lineages are Negative regulation of autophagosome maturation, Amino acid metabolic process, and Bile acid secretion, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Erlotinib response versus Negative regulation of autophagosome maturation pathway activity in UPPER_AERODIGESTIVE_TRACT (Pearson r = -0.71).

Pathway activity biomarkers of Erlotinib response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Negative regulation of autophagosome maturation →	-0.183	-0.766	.001	.036	3	8
UPPER_AERODIGESTIVE_TRACT	Amino acid metabolic process →	+0.057	+0.838	.002	.001	3	8
OVARY	Bile acid secretion →	-0.119	-0.658	.022	.001	3	8
BLOOD_Myeloma	Response to muscle inactivity →	-0.127	-0.734	.008	.010	3	8
URINARY_TRACT	L-selenocysteine biosynthetic process →	+0.146	+0.596	.014	.006	3	7
BONE	Positive regulation of T cell apoptotic process →	+0.184	+0.860	.040	.019	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Erlotinib response vs Negative regulation of autophagosome maturation — UPPER_AERODIGESTIVE_TRACT

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