Entinostat

Across CCLE and GDSC cell-line panels, response to Entinostat is significantly associated with the RNA expression of multiple genes, with BONE cell lines showing a particularly strong set of associations.

The most reproducible Entinostat response-associated genes across cancer lineages are SQSTM1, WWTR1, and TFE3, each associated with drug response in up to 10 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Entinostat response versus SQSTM1 RNA expression in BONE (Pearson r = -0.66).

Rna expression biomarkers of Entinostat response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	SQSTM1 →	-1.721	-0.935	.015	.003	3	10
LUNG_SCLC	WWTR1 →	-2.651	-0.778	.011	.020	3	10
UPPER_AERODIGESTIVE_TRACT	TFE3 →	-0.890	-0.584	.001	.002	3	9
OVARY	COL11A2 →	-0.526	-0.601	.043	.044	3	9
UPPER_AERODIGESTIVE_TRACT	TBC1D9B →	-1.221	-0.593	.013	.011	3	9
CNS	C1RL →	-1.091	-0.391	.012	.046	3	9

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Entinostat response vs SQSTM1 — BONE

Explore this scatter interactively →