Elesclomol

Across CCLE and GDSC cell-line panels, response to Elesclomol is significantly associated with the RNA expression of multiple genes, with UPPER_AERODIGESTIVE_TRACT cell lines showing a particularly strong set of associations.

The most reproducible Elesclomol response-associated genes across cancer lineages are RPS8, RPS7, and SESTD1, each associated with drug response in up to 7 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Elesclomol response versus RPS8 RNA expression in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.71).

Rna expression biomarkers of Elesclomol response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	RPS8 →	+1.526	+1.489	.016	.016	3	6
LUNG_NSCLC_LUAD	RPS7 →	+1.068	+1.895	.005	.001	3	6
LUNG_NSCLC_LUAD	SESTD1 →	-1.817	-1.740	.003	.036	3	5
BREAST	ARSA →	-1.954	-0.604	.008	.041	1	7
SKIN	RPS25 →	+0.946	+1.111	.004	.004	3	5
BLOOD_Lymphoma	SPATS2 →	-1.425	-0.497	<.001	<.001	3	5

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Elesclomol response vs RPS8 — UPPER_AERODIGESTIVE_TRACT

Explore this scatter interactively →