Elephantin

Across CCLE and GDSC cell-line panels, response to Elephantin is significantly associated with the RNA expression of multiple genes, with BONE cell lines showing a particularly strong set of associations.

The most reproducible Elephantin response-associated genes across cancer lineages are OSGIN1, DAB2, and USP31, each associated with drug response in up to 11 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Elephantin response versus OSGIN1 RNA expression in BONE (Pearson r = -0.68).

Rna expression biomarkers of Elephantin response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	OSGIN1 →	-1.799	-0.907	.001	.015	3	11
URINARY_TRACT	DAB2 →	-2.391	-0.719	.012	.019	3	10
KIDNEY	USP31 →	+0.969	+1.020	.001	.009	3	8
OESOPHAGUS	SLC7A11 →	-2.200	-0.638	.004	.003	3	8
CNS	ILF3 →	+0.443	+0.634	.017	.008	3	8
LUNG_NSCLC_LUSC	SRRD →	+1.366	+1.103	.025	.009	3	8

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Elephantin response vs OSGIN1 — BONE

Explore this scatter interactively →