Eg5_9814

Across CCLE and GDSC cell-line panels, response to Eg5_9814 is significantly associated with the protein-level pathway activity of multiple pathways, with PANCREAS cell lines showing a particularly strong set of associations.

The most reproducible Eg5_9814 response-associated pathways across cancer lineages are Calcium ion homeostasis, Intracellular calcium ion homeostasis, and Positive regulation of immune effector process, each associated with drug response in up to 9 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Eg5_9814 response versus Calcium ion homeostasis protein-level pathway activity in PANCREAS (Pearson r = -0.56).

Protein-level pathway activity biomarkers of Eg5_9814 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Calcium ion homeostasis →	-0.279	-0.865	.002	.001	3	9
PANCREAS	Intracellular calcium ion homeostasis →	-0.228	-0.867	.005	.001	3	8
LARGE_INTESTINE	Positive regulation of immune effector process →	-0.151	-0.712	.024	.004	3	8
LUNG_SCLC	Endoplasmic reticulum-plasma membrane tethering →	-0.268	-1.137	.004	.010	3	8
LUNG_NSCLC_LUAD	Cellular response to virus →	+0.148	+0.876	.005	.012	3	8
STOMACH	Protein de-ADP-ribosylation →	-1.491	-0.712	.010	.022	3	8

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Eg5_9814 response vs Calcium ion homeostasis — PANCREAS

Explore this scatter interactively →