ETP-45835

Across CCLE and GDSC cell-line panels, response to ETP-45835 is significantly associated with the shRNA pathway dependency of multiple pathways, with BLOOD_Lymphoma cell lines showing a particularly strong set of associations.

The most reproducible ETP-45835 response-associated pathways across cancer lineages are Nuclear envelope organization, Cell cycle G2/M phase transition, and Gliogenesis, each associated with drug response in up to 7 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, ETP-45835 response versus Nuclear envelope organization shRNA pathway dependency in BLOOD_Lymphoma (Pearson r = -0.81).

Shrna pathway dependency biomarkers of ETP-45835 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Nuclear envelope organization →	-0.204	-0.635	.024	.001	3	7
BREAST	Cell cycle G2/M phase transition →	-0.259	-0.136	.009	.041	3	7
BLOOD_Leukemia	Gliogenesis →	-0.141	-0.210	.013	.027	3	7
STOMACH	Autophagic cell death →	+1.472	+0.486	.002	.008	3	6
KIDNEY	Ureteric bud development →	+0.257	+0.462	<.001	.006	3	6
LUNG_NSCLC_LUSC	Animal organ maturation →	-1.206	-0.331	.010	.001	3	6

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ETP-45835 response vs Nuclear envelope organization — BLOOD_Lymphoma

Explore this scatter interactively →