ETP-45835

Across CCLE and GDSC cell-line panels, response to ETP-45835 is significantly associated with the pathway activity of multiple pathways, with BONE cell lines showing a particularly strong set of associations.

The most reproducible ETP-45835 response-associated pathways across cancer lineages are Epithelial cell-cell adhesion, Menaquinone catabolic process, and Regulation of T cell proliferation, each associated with drug response in up to 10 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, ETP-45835 response versus Epithelial cell-cell adhesion pathway activity in BONE (Pearson r = -0.61).

Pathway activity biomarkers of ETP-45835 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Epithelial cell-cell adhesion →	-0.361	-0.424	.016	.024	3	10
LUNG_NSCLC_LUSC	Menaquinone catabolic process →	-1.718	-0.297	.004	.030	3	10
OVARY	Regulation of T cell proliferation →	-0.161	-0.517	.002	.001	3	9
LARGE_INTESTINE	'de novo' AMP biosynthetic process →	+0.117	+0.415	<.001	<.001	3	9
OVARY	Response to unfolded protein →	-0.111	-0.338	<.001	.014	3	9
OESOPHAGUS	Negative regulation of smooth muscle cell migration →	-0.170	-0.302	.026	.001	3	9

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ETP-45835 response vs Epithelial cell-cell adhesion — BONE

Explore this scatter interactively →