EPZ5676

Across CCLE and GDSC cell-line panels, response to EPZ5676 is significantly associated with the total protein of multiple proteins, with OVARY cell lines showing a particularly strong set of associations.

The most reproducible EPZ5676 response-associated proteins across cancer lineages are C-Raf(BD610151), ASNS, and p62 Lck ligand, each associated with drug response in up to 7 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, EPZ5676 response versus C-Raf(BD610151) total protein in OVARY (Pearson r = 0.54).

Total protein biomarkers of EPZ5676 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	C-Raf(BD610151) →	+1.181	+0.501	<.001	.002	3	7
OVARY	ASNS →	+1.211	+0.388	.004	.006	3	7
LUNG_SCLC	p62 Lck ligand →	-1.402	-0.404	<.001	<.001	3	6
BLOOD_Lymphoma	VEGFR2 →	-1.274	-0.554	<.001	.003	3	6
UPPER_AERODIGESTIVE_TRACT	Fibronectin →	-2.414	-0.274	.010	.002	3	5
BLOOD_Leukemia	Tuberin_pT1462 →	+0.168	+0.209	.029	.016	3	5

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EPZ5676 response vs C-Raf(BD610151) — OVARY

Explore this scatter interactively →