EPZ5676

Across CCLE and GDSC cell-line panels, response to EPZ5676 is significantly associated with the shRNA pathway dependency of multiple pathways, with BONE cell lines showing a particularly strong set of associations.

The most reproducible EPZ5676 response-associated pathways across cancer lineages are Positive regulation of T cell proliferation, Mitochondrial tRNA modification, and Regulation of homotypic cell-cell adhesion, each associated with drug response in up to 9 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, EPZ5676 response versus Positive regulation of T cell proliferation shRNA pathway dependency in BONE (Pearson r = 0.81).

Shrna pathway dependency biomarkers of EPZ5676 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of T cell proliferation →	+1.553	+0.693	<.001	.017	3	9
CNS	Mitochondrial tRNA modification →	+0.860	+0.353	.016	.046	3	7
CNS	Regulation of homotypic cell-cell adhesion →	+1.102	+0.571	.015	.019	3	7
SKIN	Positive regulation of leukocyte degranulation →	+1.015	+0.444	.007	.002	3	7
UPPER_AERODIGESTIVE_TRACT	Positive regulation of mitochondrial membrane potential →	-0.085	-0.252	.015	.020	3	7
PANCREAS	Negative regulation of lipopolysaccharide-mediated signaling pathway →	-1.415	-0.448	.004	.045	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EPZ5676 response vs Positive regulation of T cell proliferation — BONE

Explore this scatter interactively →