EPZ004777

Across CCLE and GDSC cell-line panels, response to EPZ004777 is significantly associated with the RNA expression of multiple genes, with URINARY_TRACT cell lines showing a particularly strong set of associations.

The most reproducible EPZ004777 response-associated genes across cancer lineages are FBXO32, LMNA, and SDC4, each associated with drug response in up to 11 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, EPZ004777 response versus FBXO32 RNA expression in URINARY_TRACT (Pearson r = -0.46).

Rna expression biomarkers of EPZ004777 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	FBXO32 →	-2.230	-0.310	.028	.014	3	11
BLOOD_Lymphoma	LMNA →	-2.680	-0.381	.004	.006	3	11
SOFT_TISSUE	SDC4 →	-4.334	-0.339	.011	.031	3	10
BLOOD_Lymphoma	STOML1 →	-1.076	-0.407	.001	.003	3	10
URINARY_TRACT	PHB2 →	+0.937	+0.387	.020	.029	2	11
LUNG_NSCLC_LUSC	EDEM2 →	-1.178	-0.379	.003	.026	3	10

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EPZ004777 response vs FBXO32 — URINARY_TRACT

Explore this scatter interactively →