Dyrk1b_0191

Across CCLE and GDSC cell-line panels, response to Dyrk1b_0191 is significantly associated with the protein abundance of multiple proteins, with LUNG_SCLC cell lines showing a particularly strong set of associations.

The most reproducible Dyrk1b_0191 response-associated proteins across cancer lineages are RPL6, RBM28, and CGN, each associated with drug response in up to 9 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Dyrk1b_0191 response versus RPL6 protein abundance in LUNG_SCLC (Pearson r = 0.34).

Protein abundance biomarkers of Dyrk1b_0191 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	RPL6 →	+0.402	+0.675	.028	<.001	3	8
PANCREAS	RBM28 →	+0.631	+0.427	.013	.034	2	9
BLOOD_Lymphoma	CGN →	-1.309	-0.847	.003	.030	3	7
PANCREAS	UTP20 →	+1.063	+0.395	.002	<.001	3	7
BONE	NOC3L →	+0.839	+0.546	.006	.026	3	7
STOMACH	SERPINB1 →	-2.091	-0.775	.001	.007	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Dyrk1b_0191 response vs RPL6 — LUNG_SCLC

Explore this scatter interactively →