Dyrk1b_0191

Across CCLE and GDSC cell-line panels, response to Dyrk1b_0191 is significantly associated with the shRNA pathway dependency of multiple pathways, with SKIN cell lines showing a particularly strong set of associations.

The most reproducible Dyrk1b_0191 response-associated pathways across cancer lineages are Response to salt stress, Negative regulation of type B pancreatic cell apoptotic process, and Response to water-immersion restraint stress, each associated with drug response in up to 7 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Dyrk1b_0191 response versus Response to salt stress shRNA pathway dependency in SKIN (Pearson r = 0.42).

Shrna pathway dependency biomarkers of Dyrk1b_0191 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Response to salt stress →	+0.624	+0.342	.007	.004	3	7
URINARY_TRACT	Negative regulation of type B pancreatic cell apoptotic process →	-1.780	-0.346	<.001	.033	3	7
SKIN	Response to water-immersion restraint stress →	-1.209	-0.394	.004	<.001	3	6
OESOPHAGUS	Protection from natural killer cell mediated cytotoxicity →	+1.052	+0.504	.002	.010	3	6
BLOOD_Myeloma	Mitochondrial mRNA catabolic process →	+0.152	+0.814	.020	.033	3	6
BLOOD_Myeloma	Adenosine transport →	-2.019	-0.794	.007	.036	2	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Dyrk1b_0191 response vs Response to salt stress — SKIN

Explore this scatter interactively →