Doramapimod

Across CCLE and GDSC cell-line panels, response to Doramapimod is significantly associated with the shRNA dependency of multiple gene dependencies, with LUNG_SCLC cell lines showing a particularly strong set of associations.

The most reproducible Doramapimod response-associated gene dependencies across cancer lineages are RGS6, SLC35E4, and HIVEP2, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Doramapimod response versus RGS6 shRNA dependency in LUNG_SCLC (Pearson r = 0.46).

Shrna dependency biomarkers of Doramapimod response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene dependencie	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	RGS6 →	+0.188	+0.609	.006	.014	3	8
SOFT_TISSUE	SLC35E4 →	+0.373	+0.877	.044	<.001	3	7
SOFT_TISSUE	HIVEP2 →	+0.385	+0.743	<.001	.001	2	8
LARGE_INTESTINE	TMX3 →	-0.151	-0.358	.042	.040	3	7
BONE	ARHGEF12 →	-0.243	-0.453	.048	.025	2	8
OESOPHAGUS	FN1 →	+0.134	+0.500	.014	.017	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Doramapimod response vs RGS6 — LUNG_SCLC

Explore this scatter interactively →