Docetaxel

Across CCLE and GDSC cell-line panels, response to Docetaxel is significantly associated with the shRNA dependency of multiple gene dependencies, with LUNG_SCLC cell lines showing a particularly strong set of associations.

The most reproducible Docetaxel response-associated gene dependencies across cancer lineages are MSH5, CACNG6, and HSD17B14, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Docetaxel response versus MSH5 shRNA dependency in LUNG_SCLC (Pearson r = 0.52).

Shrna dependency biomarkers of Docetaxel response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene dependencie	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	MSH5 →	+0.318	+0.787	.004	.008	3	8
URINARY_TRACT	CACNG6 →	-0.210	-1.286	.031	.001	3	8
BONE	HSD17B14 →	+0.367	+0.792	.044	.004	3	8
OVARY	HTR1A →	+0.200	+0.825	.001	.010	3	8
URINARY_TRACT	GNG12 →	+0.276	+0.996	.034	.006	3	8
BONE	RDH8 →	-0.202	-0.792	.027	.004	3	8

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Docetaxel response vs MSH5 — LUNG_SCLC

Explore this scatter interactively →