Dasatinib

Across CCLE and GDSC cell-line panels, response to Dasatinib is significantly associated with the total protein of multiple proteins, with LUNG_NSCLC_LUSC cell lines showing a particularly strong set of associations.

The most reproducible Dasatinib response-associated proteins across cancer lineages are Syk, PKC-a_pS657, and PAI-1, each associated with drug response in up to 9 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Dasatinib response versus Syk total protein in LUNG_NSCLC_LUSC (Pearson r = -0.74).

Total protein biomarkers of Dasatinib response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Syk →	-3.569	-1.517	.021	.014	3	8
BONE	PKC-a_pS657 →	+1.298	+0.718	.018	.032	2	9
BONE	PAI-1 →	+3.070	+1.015	.012	.004	3	7
LIVER	PKC-a →	+1.106	+1.262	.036	.041	2	8
SKIN	Transglutaminase →	+0.982	+0.769	.017	.019	3	7
URINARY_TRACT	TAZ →	+0.478	+1.179	.010	.007	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Dasatinib response vs Syk — LUNG_NSCLC_LUSC

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