Dasatinib

Across CCLE and GDSC cell-line panels, response to Dasatinib is significantly associated with the protein abundance of multiple proteins, with BREAST cell lines showing a particularly strong set of associations.

The most reproducible Dasatinib response-associated proteins across cancer lineages are PLOD1, HAGH, and P4HA2, each associated with drug response in up to 13 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Dasatinib response versus PLOD1 protein abundance in BREAST (Pearson r = 0.56).

Protein abundance biomarkers of Dasatinib response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	PLOD1 →	+1.877	+1.001	<.001	.002	3	13
URINARY_TRACT	HAGH →	-1.383	-1.029	.006	.009	3	13
BONE	P4HA2 →	+3.201	+0.943	<.001	<.001	3	12
LIVER	DBI →	-2.787	-1.248	.005	.009	3	12
BONE	PPM1G →	-0.647	-0.594	.005	.010	3	12
LIVER	ITGB1 →	+2.335	+2.034	.001	<.001	3	12

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Dasatinib response vs PLOD1 — BREAST

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