Dasatinib

Across CCLE and GDSC cell-line panels, response to Dasatinib is significantly associated with the mutation status of multiple genes, with BREAST cell lines showing a particularly strong set of associations.

The most reproducible Dasatinib response-associated genes across cancer lineages are ADGRV1, MUC6, and FLG2, each associated with drug response in up to 4 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The box plot shows the strongest observed association, Dasatinib response grouped by ADGRV1 status in BREAST.

Mutation status biomarkers of Dasatinib response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ADGRV1 →	-3.169	-0.700	.006	.005	3	4
LARGE_INTESTINE	MUC6 →	+2.700	+0.452	.030	.017	3	3
OESOPHAGUS	FLG2 →	-2.752	-0.567	.022	.027	3	2
OESOPHAGUS	LRRK2 →	-2.807	-0.722	.027	.003	3	2
LUNG_NSCLC_LUAD	DNAH11 →	-2.000	-0.783	.007	.002	3	2
LUNG_NSCLC_LUAD	DNAH7 →	-2.169	-0.766	.030	.009	3	2

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Dasatinib response by ADGRV1 status — BREAST

Explore this box plot interactively →