Daporinad

Across CCLE and GDSC cell-line panels, response to Daporinad is significantly associated with the shRNA dependency of multiple gene dependencies, with LUNG_SCLC cell lines showing a particularly strong set of associations.

The most reproducible Daporinad response-associated gene dependencies across cancer lineages are MTF2, BCL2L1, and AIPL1, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Daporinad response versus MTF2 shRNA dependency in LUNG_SCLC (Pearson r = 0.67).

Shrna dependency biomarkers of Daporinad response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene dependencie	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	MTF2 →	+0.179	+1.711	.016	.001	3	8
LARGE_INTESTINE	BCL2L1 →	-0.630	-0.728	.030	.041	3	7
STOMACH	AIPL1 →	-0.140	-1.080	.012	.035	3	7
LARGE_INTESTINE	MRTFA →	-0.234	-1.385	.002	.016	3	7
SKIN	STK25 →	+0.190	+1.345	.001	.001	3	7
OVARY	NDUFA2 →	+0.170	+2.130	<.001	.048	3	6

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Daporinad response vs MTF2 — LUNG_SCLC

Explore this scatter interactively →