Cisplatin

Across CCLE and GDSC cell-line panels, response to Cisplatin is significantly associated with the protein-level pathway activity of multiple pathways, with BONE cell lines showing a particularly strong set of associations.

The most reproducible Cisplatin response-associated pathways across cancer lineages are Exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), Endodermal cell fate commitment, and Cell fate commitment involved in formation of primary germ layer, each associated with drug response in up to 12 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Cisplatin response versus Exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) protein-level pathway activity in BONE (Pearson r = 0.57).

Protein-level pathway activity biomarkers of Cisplatin response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+1.425	+0.811	.002	.003	3	12
BONE	Endodermal cell fate commitment →	+1.418	+1.080	<.001	.002	3	10
BONE	Cell fate commitment involved in formation of primary germ layer →	+1.418	+1.080	<.001	.002	3	10
BONE	U4 snRNA 3'-end processing →	+1.398	+0.864	.003	.004	3	9
URINARY_TRACT	Epithelial cell-cell adhesion →	-0.340	-0.961	.002	.001	3	8
BONE	Response to indole-3-methanol →	-0.549	-0.893	.025	<.001	3	8

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Cisplatin response vs Exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) — BONE

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