Cetuximab

Across CCLE and GDSC cell-line panels, response to Cetuximab is significantly associated with the protein-level pathway activity of multiple pathways, with BREAST cell lines showing a particularly strong set of associations.

The most reproducible Cetuximab response-associated pathways across cancer lineages are Negative regulation of secretion by cell, DNA damage response, signal transduction by p53 class mediator, and Monoatomic anion homeostasis, each associated with drug response in up to 7 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Cetuximab response versus Negative regulation of secretion by cell protein-level pathway activity in BREAST (Pearson r = -0.32).

Protein-level pathway activity biomarkers of Cetuximab response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Negative regulation of secretion by cell →	-0.141	-0.340	.013	.014	3	6
PANCREAS	DNA damage response, signal transduction by p53 class mediator →	+1.302	+0.345	<.001	.025	3	6
PANCREAS	Monoatomic anion homeostasis →	-1.244	-0.492	.013	.002	3	6
SKIN	Regulation of vascular permeability →	+0.400	+0.218	.034	.048	2	7
BLOOD_Leukemia	Melanosome organization →	-0.109	-0.140	.003	.006	3	6
LUNG_NSCLC_LUSC	Regulation of biological process involved in symbiotic interaction →	+0.366	+0.722	.003	.020	3	6

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Cetuximab response vs Negative regulation of secretion by cell — BREAST

Explore this scatter interactively →