Cediranib

Across CCLE and GDSC cell-line panels, response to Cediranib is significantly associated with the RNA expression of multiple genes, with UPPER_AERODIGESTIVE_TRACT cell lines showing a particularly strong set of associations.

The most reproducible Cediranib response-associated genes across cancer lineages are H3-3A, TOR4A, and TCIRG1, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Cediranib response versus H3-3A RNA expression in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.53).

Rna expression biomarkers of Cediranib response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	H3-3A →	+0.944	+0.534	.009	.011	3	8
LUNG_NSCLC_LUSC	TOR4A →	-2.389	-0.743	.013	.028	3	7
UPPER_AERODIGESTIVE_TRACT	TCIRG1 →	-1.642	-0.405	.006	.021	2	8
SOFT_TISSUE	HPCAL1 →	-2.255	-1.222	.003	.005	3	7
SOFT_TISSUE	NT5E →	-5.555	-1.209	<.001	<.001	3	7
SOFT_TISSUE	ENHO →	+1.512	+0.911	.012	.022	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Cediranib response vs H3-3A — UPPER_AERODIGESTIVE_TRACT

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