Carmustine

Across CCLE and GDSC cell-line panels, response to Carmustine is significantly associated with the mutation status of multiple genes, with LARGE_INTESTINE cell lines showing a particularly strong set of associations.

The most reproducible Carmustine response-associated genes across cancer lineages are MXRA5, FLG, and ZFPM2, each associated with drug response in up to 3 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The box plot shows the strongest observed association, Carmustine response grouped by MXRA5 status in LARGE_INTESTINE.

Mutation status biomarkers of Carmustine response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MXRA5 →	+1.764	+0.272	.005	.038	3	2
BREAST	FLG →	+1.330	+0.240	.013	.039	3	2
LUNG_NSCLC_LUAD	ZFPM2 →	+3.000	+0.313	.021	.023	3	2
LUNG_NSCLC_LUAD	RIMS2 →	-1.884	-0.278	.041	.017	3	2
LUNG_NSCLC_LUAD	ANK1 →	+2.684	+0.273	.035	.040	3	2
LARGE_INTESTINE	KMT2A →	+2.710	+0.306	.027	.033	3	2

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Carmustine response by MXRA5 status — LARGE_INTESTINE

Explore this box plot interactively →