Carmustine

Across CCLE and GDSC cell-line panels, response to Carmustine is significantly associated with the pathway activity of multiple pathways, with OVARY cell lines showing a particularly strong set of associations.

The most reproducible Carmustine response-associated pathways across cancer lineages are Integrated stress response signaling, Regulation of exosomal secretion, and Cell adhesion mediated by integrin, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Carmustine response versus Integrated stress response signaling pathway activity in OVARY (Pearson r = -0.69).

Pathway activity biomarkers of Carmustine response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Integrated stress response signaling →	-0.157	-0.605	.017	.031	3	8
SOFT_TISSUE	Regulation of exosomal secretion →	-0.141	-0.505	.008	.008	3	8
LUNG_NSCLC_LUSC	Cell adhesion mediated by integrin →	-0.172	-0.610	.038	.016	3	8
OVARY	Cellular response to unfolded protein →	-0.103	-0.684	.002	.009	3	8
OVARY	Regulation of protein localization to cell periphery →	-0.116	-0.551	.005	.022	3	8
OVARY	Quinone metabolic process →	+0.092	+0.542	.026	.022	3	8

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Carmustine response vs Integrated stress response signaling — OVARY

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