Capivasertib

Across CCLE and GDSC cell-line panels, response to Capivasertib is significantly associated with the RNA expression of multiple genes, with PANCREAS cell lines showing a particularly strong set of associations.

The most reproducible Capivasertib response-associated genes across cancer lineages are SOWAHB, L3MBTL2, and UBXN8, each associated with drug response in up to 9 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Capivasertib response versus SOWAHB RNA expression in PANCREAS (Pearson r = -0.47).

Rna expression biomarkers of Capivasertib response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	SOWAHB →	-1.271	-0.675	.008	.001	3	8
BREAST	L3MBTL2 →	+0.618	+0.844	.013	.031	3	8
STOMACH	UBXN8 →	+1.323	+1.200	.012	.003	3	8
OVARY	SHROOM3 →	-2.206	-1.173	.008	.010	3	8
OESOPHAGUS	NOTCH2NLA →	-1.027	-0.649	.042	.026	2	9
URINARY_TRACT	EPHX4 →	-1.540	-0.576	.008	.024	3	8

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Capivasertib response vs SOWAHB — PANCREAS

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