CZC24832

Across CCLE and GDSC cell-line panels, response to CZC24832 is significantly associated with the mutation status of multiple genes, with LARGE_INTESTINE cell lines showing a particularly strong set of associations.

The most reproducible CZC24832 response-associated genes across cancer lineages are BCOR, DOP1A, and NALCN, each associated with drug response in up to 3 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The box plot shows the strongest observed association, CZC24832 response grouped by BCOR status in LARGE_INTESTINE.

Mutation status biomarkers of CZC24832 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	BCOR →	+3.169	+0.236	.005	.013	3	3
LARGE_INTESTINE	DOP1A →	+2.169	+0.269	.023	.006	3	3
LARGE_INTESTINE	NALCN →	+2.169	+0.251	.023	.010	3	3
LARGE_INTESTINE	DMXL2 →	+2.061	+0.250	.004	.011	3	3
STOMACH	PCDH15 →	+1.540	+0.320	.039	.015	3	2
LUNG_NSCLC_LUAD	ANK1 →	+2.078	+0.285	.029	.033	3	2

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CZC24832 response by BCOR status — LARGE_INTESTINE

Explore this box plot interactively →