CX-5461

Across CCLE and GDSC cell-line panels, response to CX-5461 is significantly associated with the total protein of multiple proteins, with BLOOD_Lymphoma cell lines showing a particularly strong set of associations.

The most reproducible CX-5461 response-associated proteins across cancer lineages are p62 Lck ligand, XBP1, and Rab25, each associated with drug response in up to 7 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, CX-5461 response versus p62 Lck ligand total protein in BLOOD_Lymphoma (Pearson r = -0.52).

Total protein biomarkers of CX-5461 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	p62 Lck ligand →	-1.334	-1.152	<.001	<.001	3	7
URINARY_TRACT	XBP1 →	+0.372	+1.062	.022	.002	3	7
LARGE_INTESTINE	Rab25 →	-0.678	-0.790	.032	.007	3	6
URINARY_TRACT	PDK1_pS241 →	-0.674	-0.767	.010	.023	3	5
LUNG_NSCLC_LUSC	SF2 →	+0.406	+1.030	.028	.039	2	6
OVARY	alpha-Catenin →	-0.713	-1.001	.005	.010	3	5

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CX-5461 response vs p62 Lck ligand — BLOOD_Lymphoma

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