CRT0105950

Across CCLE and GDSC cell-line panels, response to CRT0105950 is significantly associated with the protein abundance of multiple proteins, with BONE cell lines showing a particularly strong set of associations.

The most reproducible CRT0105950 response-associated proteins across cancer lineages are FLNB, ERP44, and TM9SF4, each associated with drug response in up to 9 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, CRT0105950 response versus FLNB protein abundance in BONE (Pearson r = -0.53).

Protein abundance biomarkers of CRT0105950 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	FLNB →	-1.160	-0.510	<.001	<.001	3	9
PANCREAS	ERP44 →	-0.727	-0.673	<.001	<.001	3	8
LUNG_NSCLC_LUAD	TM9SF4 →	-0.579	-0.356	.010	.017	3	8
OVARY	CGN →	-1.166	-0.391	.018	.004	3	8
PANCREAS	ETHE1 →	-1.464	-0.612	.003	.004	3	8
LIVER	PITRM1 →	-1.386	-0.772	.010	.004	3	8

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CRT0105950 response vs FLNB — BONE

Explore this scatter interactively →